Choroba Addisonsa. Hiperpigmentacja reprezentująca uwydatnienie normalnej pigmentacji ręki pacjenta z chorobą Addisonsa (po lewej). Dla porównania, ręka normalnej osoby, dopasowanej pod względem pigmentacji etnicznej, jest pokazana po prawej stronie.
Pigmentacja wywołana lekami: amiodaron Uderzająca łupkowo-szara pigmentacja w fotodystrybucji twarzy. Niebieski kolor (ceruloderma) jest spowodowany odkładaniem się melaniny i lipofuscyny zawartej w makrofagach i komórkach śródbłonka skóry właściwej. Pigmentacja jest odwracalna, ale jej całkowite ustąpienie może trwać do roku lub dłużej. U tego pacjenta zniknięcie cerulodermy trwało 33 miesiące.
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